Numerous studies have demonstrated that microbiota is also a key contributor to obesity 16, 17, 18, 19, 20, 21, 22, 23. Dietary excesses and also host genetic factors are the main obesity causes in humans 5, with heritability estimates ranging from 0.40 to 0.70 in humans 6 and farm animals 7, 8, and some loci already identified for obesity (e.g., MC4R, leptin, Fob, and FTO) 9, 10, 11 and obesity-related metabolic disorders (NOD 1,2 12, apolipoprotein E 13, 14, and CD 14 15). Therefore, obesity remains a major public health and also an economic concern. Overweight and obesity have medical consequences such as increased risk of diabetes, cardiovascular disease, cancer, or depression 2, 3, 4. Obesity has markedly increased worldwide over the past 40 years, and projections indicate that global obesity prevalence will exceed 18% in men and 21% in women by 2025 1. Importantly, the results of this study are of relevant interest for the efficient development of strategies fighting obesity. We also differentiated between host-genetically influenced microbial mechanisms regulating lipid deposition in body or intramuscular reservoirs, with only 28 out of 122 MGs commonly contributing to both.
This work elucidates that microbial biosynthesis lipopolysaccharides, peptidoglycans, lipoproteins, mucin components, and NADH reductases, amongst others, are influenced by the host genetic determination for lipid accretion in muscle. After 10 generations of divergent selection for intramuscular fat in rabbits and 4.14 phenotypic standard deviations (SD) of selection response, we applied a combination of compositional and multivariate statistical techniques to identify 122 cecum microbial genes with differential abundances between the lines (ranging from −0.75 to +0.73 SD).
Our study provides an exhaustive comparison of the microbiome core functionalities (captured by 3,936 microbial gene abundances) between hosts with divergent genotypes for intramuscular lipid deposition.
0 kommentar(er)
